Haiyan Fu MD., PhD

Associate Professor
National Clinical Research Center for Kidney Disease
State Key Laboratory of Organ Failure Research
Division of Nephrology, Nanfang Hospital,Southern Medical University

Dr. Fu has long-standing interests in investigating the pathogenesis of renal injury/repair which is associated with the changes of kidney local microenvironments. Based on her research, she for the first time raised the novel notion “Niche” during kidney diseases progression and she has revealed that Tenascin-C is the major component of the Niche in kidney within the field. 

Dr. Fu has produced more than 30 papers in well-respected scientific journals including the Journal of American Society of Nephrology (JASN, impact factor: 8.966) and Gastroenterology (impact factor: 18.392). She also serves as an editorial member of the Journal of Urology and Research, as well as the guest editor of the Journal of Biomarkers. 

Dr. Fu earned her medical degree from the Army Medical University. She then completed her master and PhD degree at the Air Force Medical University. From 2013 to 2016, Dr. Fu worked as a post-doctoral fellow at the University of Pittsburgh, School of Medicine. During this period, her research was invited to be presented at the annual kidney week held by the American Society of Nephrology. 

Currently, as an Associate Professor, Dr. Fu belongs to the following academic societies, the American Society of Nephrology, the American Society of Molecular Biology, the Chinese Society of Biochemistry and Molecular Biology, and the Chinese Pharmacological Society. She also included in the “the SMU Recruitment Program of Global Experts” in 2013 and belonged to the Guangdong Science Foundation Innovative Group program, as well as the SMU Innovative Research Team Culturing Program. Meanwhile, she is also the candidate of the “Outstanding Young Scientists Fostering Project” sponsored by the Nanfang Hospital. 

Education

Army Medical University (Third Military Medical University), M.D 1996-2001
Air Force Medical University (Fourth Military Medical University), M.S 2003-2006
Air Force Medical University (Fourth Military Medical University), Ph.D 2007-2009
University of Pittsburgh, Post-doctoral fellow 2013-2016

Selected Research and Publications

1.Fu H, Tian Y, Zhou L, Zhou D, Tan RJ, Stolz DB, Liu Y. Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis. J Am Soc Nephrol. 2017;28(3):785-801.

2.Fu H, Liu Y. Loss of Klotho in CKD Breaks One's Heart. J Am Soc Nephrol. 2015,26(10):2305-2307.

3.Fu H, Yang G, Wei M, Liu L, Jin L, Lu X, Wang L, Shen L, Zhang J, Yao L, Lu Z. RNA binding protein QKI is a direct target of C/EBPα and delays the macrophage differentiation through negatively targeting CSF1R expression. Molecular Biology of the Cell. 2012;23(9):1628-1635. 

4.Fu H, Yang, G, Lu F, Wang R, Yao L, Lu Z. Transcriptional up-regulation of restin by all-trans retinoic acid through STAT1 in cancer cell differentiation process. Biochemical and Biophysical Research Communications. 2006;343(4):1009-1016. 

5.Yang, G, Fu H(Co-first Author), Zhang J, Lu X, Yu F, Jin L, Bai L, Huang B, Shen L, Feng Y, Yao L, Lu Z. RNA-Binding Protein Quaking, a Critical Regulator of Colon Epithelial Differentiation and a Suppressor of Colon Cancer. Gastroenterology. 2010;138(1):231-240 e231-235.

6.Zhang J, Fu H(Co-first Author), Xu Y, Niu Y, An X. Hyperoside reduces albuminuria in   diabetic nephropathy at the early stage through ameliorating renal damage and podocyte injury. J Nat Med. 2016;70(4):740-748.

7.Liu S, Chen P, Zhang N, Sun L, Dai G, Zhu L, Li C, Zhao Y, Zhang L, Fu H(Correspondence Author), Ju W. Comprehensive characterization of the in vitro and in vivo metabolites of limonin in human samples using LC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:226-232.

Research Founding 

1.  Natural Science Foundation of China (No: 81770737) 2018.01-2021.12. Role: PI
2.  Natural Science Foundation of China (No: 31371394) 2014.01-2017.12. Role: PI
3.  Southern Medical University, “Outstanding Young Scientists Fostering Project”  
     2015.07-2018.12. Role: PI
4.  Natural Science Foundation of China (No:30900732) 2010.01-2012.12. Role: PI
5.  Young talent to support of Fourth Military Medical University 2011.01-2013.12. Role: PI