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Fan Fan Hou


Fan Fan Hou, MD., PhD

Professor & Chief Physician
Director of the National Clinical Research Center for Kidney Disease
Director of the State Key Laboratory of Organ Failure Research
Director of the Guangdong Provincial Institute of Nephrology 
Director of Nephrology Department in Nanfang Hospital

Dr. Hou is the Academician of the Chinese Academy of Sciences and the Academician of the Third World Academy of Sciences (TWAS). She is currently the Councilor of the ISN, the member of work group for KDIGO Clinical Practice Guidelines, and the Vice-President of the Chinese Society of Nephrology.

Dr. Hou is board certified in internal medicine and nephrology. Her clinical research interests lie in CKD and AKI. She had been the Principal Investigator of several large clinical trials such as ESBARI, ROAD, and CSPPT-CKD. In basic research, her interests focus on renal fibrosis and the mechanisms underlying CKD progression. She is the Principal Investigator of the Major State Basic Research Development Program of China.

Dr. Hou has published hundreds of papers in top-notch, peer-reviewed journals such as N Engl J Med, JAMA, JAMA Intern Med, J Am Soc Nephrol, and Kidney Int. She had won three times the National Award for Advances in Science and Technology by the State Council of China and the National Award for Best Clinic Service by Chinese Medical Doctor Association. She was the winner of the Young Investigator Award by APSN (1992) and the First Prize Medal for ISN Fellow by the ISN (2001).

Selected Research and Publication

1.Hou FF, Zhang X, Zhang GH, Xie D, Chen PY, Zhang WR, Jiang JP, Liang M, Wang GB, Liu ZR, Geng RW. Efficacy and safety of benazepril for advanced chronic renal insufficiency.N Engl J Med. 2006 Jan 12; 354(2):131-40.

2.Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF, Tang G, Wang B, Chen D, He M, Fu J, Cai Y, Shi X, Zhang Y, Cui Y, Sun N, Li X, Cheng X, Wang J, Yang X, Yang T, Xiao C, Zhao G, Dong Q, Zhu D, Wang X, Ge J, Zhao L, Hu D, Liu L, Hou FF; CSPPT Investigators. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. 2015.313(13):1325-1335. 

3.Xu X, Qin XH, Li YB, Sun DH, Wang J, Liang M, Wang BY, Huo Y, Hou FF.   Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease: The Renal Substudy of the China Stroke Primary Prevention Trial. JAMA Intern Med. 2016.176(10):1443-1450.

4.Cao W, Li AQ, Wang LL, Zhou ZM, Su ZX, Bin W, Wilcox CS, Hou FF. A salt-induced reno-cerebral reflex activates RAS and promotes CKD progression. J Am Soc Nephrol. 2015.26(7):1619-1633.

5.Ai J, Nie J, He JB, Guo Q, Li M, Lei Y, Liu YH, Zhou ZM, Zhu FX, Liang M, Cheng YX, Hou FF.GQ5 hinders renal fibrosis in obstructive nephropathy by selectively inhibiting TGF-β-induced Smad3 phosphorylation. J Am Soc Nephrol. 2015.26(8):1827-1838. 

6.Wei XF, Xia Y, Li F, Tang Y, Nie J, Liu YH, Zhou ZM, Zhang HQ, Hou FF.   Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis. J Am Soc Nephrol. 2013.24(9):1387-1398.

7.Xu X, Wang GB, Chen N, Lu T, Nie S, Xu G, Zhang P, Luo Y, Wang YP, Wang XB, Schwartz J, Geng J, Hou FF. Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China. J Am Soc Nephrol. 2016. 27(12):3739-3746.

8.Yang XB, Chen CB, Tian JW, Zha Y, Xiong YQ, Sun ZL, Chen PY, Li J, Yang TC, Ma CS, Liu HF, Wang XB, Hou FF. Urinary angiotensinogen level predicts acute kidney injury in acute decompensated heart failure: a prospective, two-stage study. J Am Soc Nephrol. 2015.26(8):2032-2041. 

9.Yang X, Chen C, Teng S, Fu X, Zha Y, Liu H, Wang L, Tian J, Zhang X, Liu Y,Nie J, Hou FF. Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery. J Am Soc Nephrol. 2017 Nov.28(11):3373-3382.

10.Cao W, Cui S, Yang L, Wu C, Liu J, Yang F, Liu Y, Bin J, Hou FF.   Contrast-Enhanced Ultrasound for Assessing Renal Perfusion Impairment and Predicting Acute Kidney Injury to Chronic Kidney Disease Progression. Antioxid Redox Signal. 2017 Dec 10.27(17):1397-1411.

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