Jun Ai, MD

Associated chief physician & lecturer
National Clinical Research Center for Kidney Disease
State Key Laboratory of Organ Failure Research
Division of Nephrology, Nanfang Hospital,Southern Medical University

Dr. Jun Ai is a nephrologist who cares for adult patients with acute or chronic kidney disease. His research interests include Peritoneal Dialysis and ultra-filtration mechanisms, mechanisms in AKI: Numb in renal autophagy, and new therapeutic strategies for primary Membranous Nephropathy.

Ai earned his medical degree from the Department of Internal Medicine, Peking Union Medical College Hospital, Beijing in 2006. He then worked in the Division of Nephrology, Nanfang hospital of Southern Medical University as a Resident, a Chief Resident, an attending physician from 2006 to 2014 respectively. And now he is an associate chief physician. He has received a one-year refresher doctor training in Department of Internal Medicine, Peking Union Medical College Hospital in 2007-2008.
 
Ai have accomplished the research work in the field of anti-fibrotic small molecules and the underlying mechanism, and he had published the work in JASN, and obtained two Chinese patent certificates and one United States patent in 2015. He had also obtained two grants of the National Natural Science Foundation of China.

More about Jun Ai 

Education and Working Experience
M.D Degree           Peking Union Medical College, Beijing, China M.D. in clinical Medicine
Resident                 Division of Nephrology, Department of Internal Medicine, Nanfang Hospital, China
Refresher Doctor     Department of Internal Medicine, Peking Union Medical College Hospital, China.
Chief resident          Division of Nephrology, Department of Internal Medicine, Nanfang Hospital
Attending physician and lecturer              Division of Nephrology, Department of Internal Medicine
Associated chief physician and lecturer     Division of Nephrology, Nanfang Hospital
 
Contacts

Address: Address:1838 North Guangzhou Ave, Nanfang Hospital, Southern Medical University ,Guangzhou, P.R.China
Working Hours: Monday to Friday 8:00 a.m. - 5:30 p.m
Outpatients time: Tuesday morning and Wednesday afternoon

Research Projects

1. Peritoneal Dialysis and ultra-filtration mechanisms.
2. Mechanisms in AKI: Numb in renal autophagy.
3. New therapeutic strategies for primary Membranous Nephropathy.

Currently Research grants

1.The National Natural Science Foundation of China (grants 81770765) 1/1/2018-12/31/2021
 “The function and mechanism in peritoneal dialysis ultra-filtration”.

2. The National Natural Science Foundation of China (grants 81500514) 1/1/2016-12/31/2018
  “The function and mechanism of Numb in renal autophagy”.

Selected Research and Publication

1.Ai Jun, Nie Jing, He Jiangbo, Guo Qin, Li Mei, Lei Ying, Liu Youhua, Zhou Zhanmei, Zhu Fengxin, Liang Min, Cheng Yongxian, Hou Fan Fan. GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy bySelectively Inhibiting TGF-beta-Induced Smad3 Phosphorylation. J Am Soc Nephrol. 2015.8.01, 26(8): 1827~1838.

2.Yan Yong-Ming, Ai Jun, Zhou Li-Li, Chung Arthur C. K. Li Rong, Nie Jing, Fang Ping, Wang Xin-Long, Luo Jie, Hu Qun, Hou Fan-Fan, Cheng Yong-Xian. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum. Organic Letters. 2013.11.1, 15(21):5488~5491.

3.Zhanmei Zhou, Zhen Hu, Mei Li, Fengxin Zhu, Hao Zhang, Jing Nie, and Jun Ai. QiShenYiQi Attenuates Renal Interstitial Fibrosis by Blocking the Activation of β-Catenin. PLoS One. 2016.9.16; 11(9)

4.Li Mei, Hu Liping, Zhu Fengxin, Zhou Zhangmei, Tian Jianwei, Ai Jun. Hepatitis B virus X protein promotes renal epithelial-mesenchymal transition in human renal proximal tubule epithelial cells through the activation of NF-B. International Journal of Molecular Medicine, 2016.8.01, 38(2): 513~520.

5.Du Song-lin, Zeng Xiang-zhen, Tian Jian-wei, WanJun, He Jian-xing, Ai Jun. Advanced oxidation protein products in predicting acute kidney injury following cardiac surgery. Biomarkers. 2015.01.01, 20(3): 206~211.

Patents

1.China Invention Patent (201210111642.X)  Date of patent: 2015.5.6
 “Use of Urushiol compounds in the preparation of drugs for inhibiting renal tissue fibrosis”.
2.China Invention Patent (201210111641.5)   Date of patent: 2015.8.5
 “Use of Urushiol compounds in the preparation of drugs for inhibiting liver tissue fibrosis”.
3.United States Patent (US 9139502B2)  Date of patent: 2015.9.22
 “Use of an Urushiol compound in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation”.